Diphenhydramine price in the US
Updated 2026-11-04 · USD · United States
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Current Diphenhydramine prices in the US
3 offers from 1 pharmacy: $3.69 to $4.39, across different strengths, forms and pack sizes, so compare like with like. Lowest listed: Diphenhydramine HCI Allergy Relief Tablets - 100ct - up&up™ at Target.
| Product | Pharmacy | Price | Per unit |
|---|---|---|---|
| Diphenhydramine HCI Allergy Relief Tablets - 100ct - up&up™ | Target | $3.69 | $0.04 |
| Ibuprofen PM Caplets - Diphenhydramine (NSAID) - 20ct - up&up™ | Target | $3.99 | $0.20 |
| Children's Diphenhydramine Allergy Relief Liquid - Bubblegum - 4 fl oz - up&up™ | Target | $4.39 | – |
Listed prices as shown on each pharmacy’s website, checked October 27, 2026. This is a dated snapshot, not a live price, and excludes delivery fees, discounts and insurance cover. Prices change often, so confirm on the pharmacy site before you buy.
Active ingredient (WHO INN): Diphenhydramine · ATC code R06AA02
Prices by strength and form
| Product | Offers | Lowest | Highest |
|---|---|---|---|
| tablet | 1 | $3.69 | $3.69 |
| capsule | 1 | $3.99 | $3.99 |
| – | 1 | $4.39 | $4.39 |
Lowest listed price (tablet) in earlier checks
- October 27, 2026: $3.69
- October 25, 2026: $3.69
Frequently asked questions
How much is Diphenhydramine in the US?
In our check on October 27, 2026, Diphenhydramine cost from $3.69 at Target. 1 pharmacy listed it, up to $4.39. Prices change, so compare live before you buy.
Related availability in United States
Health calculators for Diphenhydramine users
Whether Diphenhydramine needs a prescription in the US depends on the strength and pack size. Ask a pharmacist before you buy.
MediHub does not sell medicines. We check publicly listed pharmacy availability and prices and send you to the retailer. This page is for availability and price information, not medical advice.
For a price spread, copay check, medication list, or pill identifier, open United States drug price comparison or the prescription price guide.
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